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KMID : 1140120080130020130
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Cancer Prevention Research
2008 Volume.13 No. 2 p.130 ~ p.136
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Growth Inhibition of Human Hepatocarcinoma Cells by Water Extract of Euphorbiae humifusae was Associated with the Inhibition of Prostglandin E2 and NO Synthesis
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Seo Sang-Ho
Shin Dong-Yeok
Hong Su-Hyun
Park Sang-Eun
Kim Won-Ill
Park Dong-Il
Choi Yung-Hyun
Hong Sang-Hoon
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Abstract
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Euphorbiae humifusae wind is a traditional medicinal plant generally used in Oriental medicine therapy. Previous studies have shown that E. humifusae exhibits anti-proliferative and antioxidant activities. However, the mechanism responsible for the anticancer effects of E. humifusae not clearly understood. In the present study, we investigated the anti-proliferative effects by the water extract of E. humifusae (WEEH) in Hep3B human hepatocarcinoma cells. It was found that WEEH could inhibit the cell growth in a dose-dependent manner as measured by MTT assay, which was associated with morphological change and apoptosis induction. Furthermore, WEEH treatment decreased the level of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthease (iNOS) expression without significant changes in the expression of COX-1, which was correlated with a decrease in prostaglandin E2 (PGE2) and NaNO2 synthesis. These findings suggest that WEEH may be a potential chemopreventive and chemotherapeutic agent for the control of human cancer cells. (Cancer Prev Res 13, 130-136, 2008)
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KEYWORD
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Euphorbiae humifusae, Hep3B, COX-2, iNOS
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